Cancer and Immunity
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Contents
Immune
System Basics
Immune Building Agents:
1. Cats Claw (Una de Gato)
2. Olive Leaf
3. Essiac Herbs
4. Hoxsey Herbs
5. Fish Oil
6. Mistletoe
7. Medical Mushrooms
8. Bovine Tracheal Cartilage (BTC)
9. Ukrain
10. Addition Factors to Boost Immunity
Summary
The human immune system is a magnificent and well-coordinated network of
cells, organs, and glands. An optimized immune system is the key to good
health and longevity. There is little doubt that the immune system plays
a critical role in deterring cancer. Many in the forefront of cancer research
in fact regard cancer as an indication of immune weakness. The fact is,
that a weak immune response has a direct and inverse correlation with many
types of cancer. Restoring the immune system function is perhaps the most
critical step to be taken in any cancer treatment program. Having a strong
immune system is a key component of any anti-cancer protocol, traditional
or otherwise.
Immune System Basics
The key elements of our immune system are the
T and B-lymphocytes. B-lymphocytes are in charge of humoral
immunity. They are primarily concerned with the manufacturing and deployment
of immunoglobilins. Immunoglobilins can act what they determined to be antigens,
and for this reason, these immunoglobulins are known as antibodies.
There are many different kinds of antibodies. They are classified into five
five major classes, IgA (immunoglobulin A), IgD, IgG, IgM and IgE. Each
class has a special function. Together, they ensure that all foreign bodies
are recognized and destroyed.
T-lymphocytes are in charge of cellular immunity. They act as a command
post from which most orders for the immune system flows. They stimulate
macrophages and B-lymphocytes. These are the soldiers vital for the
ultimate protection of the body against disease such as bacterial infections,
strong viruses, most fungi, cancer, and some parasitic infections. This
system protects the body against most chronic, disabling and fatal diseases.
A small, but important, sub-group of T-lymphocytes, the T-helper cells,
also known as CD4s, control the various WBCs, by issuing chemical codes
known as cytokines. Examples of cytokines include interleukins and
interferons. T-helper cells, therefore, coordinate the combined
effort of the WBCs to contain and destroy any non-self substance, once detected.
Without T-helpers, the deeper immune responses that keep the body healthy
would be unable to function on an optimal basis.
To keep the lymphocytes in check, the body makes T-suppressor or T-8
cells. These secrete counterbalancing cytokines to down-regulate the
destructive activities of cytokines from other WBCs. This is an important
function and serves to protect the host. The proper ratio of T-helper to T-suppressor cells
is critical as it maintains a balance between necessary aggressive action,
that kills the enemy, and all out generalized destruction, that may target
healthy cells as well.
Immune Building Agents
1. Cats Claw (Una de Gato) - A woody vine of up
to 100 feet in length, Cat's Claw is found on trees in the rain forests
of the Andes Mountains, particularly in Peru. Although virtually unheard
of in the United States until recently, the beneficial effects of the Peruvian
herb Uncaria Tomentosa, commonly known as "una de gato" in Spanish and "cat's
claw" in English, have been studied at research facilities in Peru, Austria,
Germany, England, Hungary and Italy, since the 1970's. These studies suggest
that the herb may be beneficial in the treatment of arthritis, bursitis,
allergies, diabetes, lupus, chronic fatigue syndrome, cancer, herpes, organic
depression, menstrual irregularities and disorders of the stomach and intestines.
It
far surpasses such well-known botanicals as Echinacea, Golden Seal, Astragalus,
and Siberian Ginseng in its anti-bacterial and immune building properties.
Unique alkaloids in una de gato seem to enhance the immune system in a general
way. These alkaloids have a pronounced effect on the ability of white blood
cells to engulf and digest harmful microorganisms and foreign matter. Laboratory
testing has shown these alkaloids to have a pronounced enhancement effect
on phagocytosis (the ability of the white blood cells and macrophages to
attack, engulf and digest harmful micro-organisms, foreign matter and debris).
The most immunologically active alkaloid appears to be isoteropodine or
isomer A. Cat's claw has also been shown
to increase the production of leukocytes and specifically T4 lymphocytes,
thus blocking the advance of many viral illnesses.
In addition to its immune-stimulating and anti-inflammatory actions, Cat's
Claw has antioxidant properties that could reduce the risk of the hardening
of arteries and heart disease. Traditionally, the bark of the root was considered
the medicinal part, but bark from the vine is now sold instead.
Dosage: Tea: 1 cup of tea 3 times per day; Tincture: 1 to 2 milliliters
up to 2 times per day; Dry extract: 20 to 60 milligrams per day; Cancer
in remission: 2 to 6 grams a day, and in advanced cases, up to 3 times as
much can be taken if an aggressive stance is taken. Because Cat's
Claw may cause the immune system to reject foreign cells, anyone with organ or tissue transplants should avoid it, as should
those with autoimmune illnesses, multiple sclerosis, or tuberculosis. Cat's
Claw should also be avoided during pregnancy, and is not for children
under 2 years of age. It may block platelets from forming clots, so
those on blood thinners such as aspirin or warfarin should be used
careful.
2.
Olive Leaf. Health professionals first started using Olive Leaf
extract in the mid 1990s when it became available. From research and clinical
experience to date, olive leaf supplementation may be beneficial in the
treatment for conditions caused by, or associated with, a virus, retrovirus,
bacterium or protozoan. Among the treatable conditions are: influenza,
the common cold, meningitis, Epstein-Barr virus (EBV), encephalitis, herpes
I and II, human herpes virus 6 and 7, shingles (Herpes zoster), HIV/ARC/AIDS,
chronic fatigue, hepatitis B, pneumonia, tuberculosis, gonorrhea, malaria,
dengue, bacteremia, severe diarrhea, blood poisoning and dental, ear, urinary
tract and surgical infections.
Olive leaf has also been known to boost energy.
After a continued use of olive leaf, people are more likely to have a greater
sense of well-being. Often times, olive leaf extract produces an infusion
of energy, giving those who use it an "upper" feeling. Olive leaf helps
sustain energy during exercise and acts as a good source of pep for those
who are not active. Many people who live stressful lives or who may be particularly
susceptible to colds and viruses may benefit from the long-term use of olive
leaf as a preventative agent. Some patients have expressed other unexpected
benefits of olive leaf, including improved psoriasis, normalization of heart
beat irregularities and less pain from hemorrhoids, toothaches and chronically
achy joints.
The active ingredient in olive leaf is called Oleuropein. It
was found to be one ingredient in a compound produced by the olive tree
that makes it particularly robust and resistant against insect and bacterial
damage. From a technical angle, oleurpein is an iridoil, a structural class
of chemical compounds found in plants. It is present in olive oil, throughout
the olive tree, and is, in fact, the bitter material that is eliminated
from the olives when they are cured.
Research suggests that olive leaf may be a "true anti-viral" compound because it
appears to selectively block an entire virus specific system in the infected
host. It then appears to offer healing effects not addressed by pharmaceutical
antibiotics. Olive leaf's broad killing power includes:
· An ability to interfere with critical
amino acid production for viruses.
· An ability to contain viral infection and/or
spread by inactivating viruses by preventing virus shredding,
budding or assembly at the cell membrane.
· The ability to directly penetrate infected
cells and stop viral replication.
Olive leaf extract also has a powerful immune system boosting effect by
means of increasing phagocytosis in white
blood cells (the effect is the destruction of foreign bacteria
and viruses that are literally gobbled up).
Dosage: Standardized extract is best, containing at least 20 % active
ingredient. 500mg-2000 mg a day.
3. Essiac Herbs - A very select
blend of herbs which has been passed up through the Ojibwa medicine men,
a native Indian tribe in Canada. In 1922, it landed in the hands of an Ontario,
Canadian nurse named Rene Caisse. Although Rene was not ill at the time;
she asked for the formula just in case she might ever need it. Unfortunately,
and ironically, a member of her family had been diagnosed with cancer and
was given six months to live. Sensing that she had "nothing to lose" Rene
decided to test this tea on her dying aunt. The result: the woman went on
to live another 21 years, eventually dying of natural causes. Nurse Caisse
named this special anti-cancer blend of tea "Essiac".
Inspired by her aunt's success with the tea, Rene Caisse began to offer
the remedy's recipe to anyone who asked for it. Soon thereafter, Dr. Charles
Brusch (personal physician to former President John F. Kennedy) learned
of the successes of the tea and became a research partner with Rene.
The blend consists of the following four herbs,
which work together to purify the blood, aid cell repair, and ease pain.
Burdock Root (67.7%) reportedly decreases cell mutation
and inhibits tumors. It is used to reduce and prevent gall and kidney stones.
It has vitamin A and selenium, which help eliminate free radicals. Its chromium
helps regulate blood sugar. A Japanese scientist at Nagoya University
in 1984 discovered burdock contains a new type of desmutagen, a substance
called B-factor that is uniquely capable of reducing cell mutation either
in the absence or in the presence of metabolic activation. In general, it
acts as a cleanser and strengthening agent. Two studies conducted at the
National Cancer Institute reported anti-tumor activity of burdock in animal
tumor systems, while two others reported no significant activity for this
herb. The National Cancer Institute tested burdock 14 times, with one sample
showing activity, though not considered significant, in the P388 mouse leukemia
system. Benzaldehyde, which has been isolated from burdock, has shown
anti-tumor activity in some animal tests.
Slippery Elm's (5%) inner bark
is rich in calcium, magnesium, and vitamins A, B, C, and K. This is reported
to soothe organs, tissues and mucus membranes. It is considered especially
helpful to the lungs. It is also reported to aid digestion and to relieve
asthma. It dissolves excess mucous deposited in organs, tissue, lymph glands,
nerve channels, and eases wastes through alimentary canal. Slippery Elm
has been tested at National Cancer Institute seven times using samples from
various parts of the United States and found no anti-tumor activity in mouse
leukemia systems. Slippery elm contains beta-sitosterol and a polysaccharide,
both of which have been reported to have anti-tumor activity in an animal
tumor models.
Sheep Sorrel (21.6%) is known as
a traditional folk remedy for cancer. It is also reported to relieve internal
ulcers, and if applied externally, to clear skin problems such as eczema,
ringworm and herpes. It's reported to nourish the glandular system because
it is rich in vitamins, minerals and trace elements. Its active ingredients,
aloe emodin, isolated from sorrel, do show significant anti-leukemic activity.
It is responsible for the destruction of cancer cells in the body according
to Dr. Chester Stock at Sloan-Kettering in New York. The National Cancer
Institute tested one sample of sorrel from Taiwan and found no activity
in mouse leukemia systems. The compound aloe emodin and emodin have been
isolated from sorrel and have shown activity in some animal test systems.
Turkey Rhubarb root (5%) (Indian
rhubarb) is reported to act as a gentle laxative and purges the body, especially
the liver, of waste and toxins. It is also considered to aid digestion and
to carry oxygen throughout the body. It contains a substance called rhein
that inhibits disease-causing bacteria in the intestines and also reduces
fever and inflammation. Anti-tumor activity was demonstrated with Indian
rhubarb in the sarcoma-37 animal test system. Laboratory tests, on a single,
isolated compound from one herbal formula, fail to address the synergistic
potency of all the herbs when combined together. The National Cancer Institute
tested two samples of Indian rhubarb from Poland and found no ant-tumor
activity in mouse leukemia systems. Another type of Indian rhubarb, Peltiphyllum
peltatum, was tested three times, and none was found active in mouse leukemia
systems. Components of Indian rhubarb include emodin and catechin that
have shown anti-tumor activity in some animal test systems.
In addition to it's reported effects on cancer, this tea is reported to
be beneficial in the treatment of AIDS, diabetes, inflammatory skin problems,
liver ailments, normalization of the thyroid, stomach ulcers and other degenerative
diseases. Due to its immune boosting properties, many take it as a cold
remedy.
Extensive clinical experience showed that this
blend of tea breaks down nodular masses to a more normal tissue, while greatly
alleviating pain. Many patients would report an enlarging and
hardening of the tumor after a few treatments. Then the tumor would start
to soften. Discharge of large amounts of pus and fleshy material has also
been reported. Masses of diseased tissue were sloughed off in persons with
breast, rectum, and internal cancers as the cancer shrinks. It is theorized
these herbs reduced tumor growth while the other herbs acts as blood purifiers,
carrying away destroyed tissue as well as infections related to malignancy.
Strengthening of the body's immune system
is probably the primary mechanism of action of Essiac tea. In
fact, Nurse Caisse maintained that even if a tumor does not disappear, it
is forced to regress. In fact, she recommends the use of these herbs for 6 to 8 treatments before
any surgical procedure, and then given once a week for at least 3 months
after surgery, during remission, to supply the body with the resistance
to a recurrence.
Essiac tea comes in a variety of forms commercially.
The best and most effective form is to brew the tea from raw herbs
purchased from herbal suppliers. Strict instructions must be
followed. If that is too troublesome, taking an extract or essence of such a tea offers a good and safe alternative.
Some prefer the tea to come bottled and ready for consumption. This
is good for general preventive healthcare but not for cancer treatment due to its low potency.
Few companies offer these herbs in a capsule format, but the efficacy
of such crushed herb capsule is unknown. Those who are serious
about this herbal tea blend should consider the raw herb or the essences
format. Through the years, researchers have tried to improve the blend with
additional proprietary ingredients, including other herbs and medical mushrooms.
One word of caution: A popular commercial version of this tea is called
Flor-essence. It incorporates red clover and watercress together with the
original four herbs. Those with hormone sensitive tumors should refrain
from red clover that has estrogen like effect.
Dose: Dosage varies from one ounce a week to two ounces three
times a day. More is not recommended. The common recommended
dosage is 2 oz diluted in 2 to 3 oz of body temperature water to be taken
once a day for first 10 days, later reduced to 1 oz in the same dilution
per day. The maximum recommended dose is 6 ounces a day in 2 -3 divide doses.
This is recommended for 1 to 2 years or longer, with amounts eventually
being further reduced to 2 or 3 times per week.
People with bowel obstructions, kidney disease, ulcers, colitis, lactating
mothers, pregnant women, and children under 12 should not consume this blend
of tea. It should be taken with caution with people taking anticoagulant
therapy, diabetic or patient on digoxin.
4. Hoxsey Herbs. In the early 1900's, Harry Hoxsey developed
an herbal formula that he believed was effective for the treatment of cancer.
It consists of two remedies, one to be used externally, the other
internally. The external mixture is said to be selectively destructive
of cancerous tissue and consists of a red paste containing antimony trisulfide,
zinc chloride, and bloodroot, and a yellow powder containing arsenic sulfide,
sulfur, and talc. The internal mixture is a liquid containing licorice,
red clover, burdock root, stillingia root, barberry, cascara, prickly ash
bark, buckthorn bark, and potassium iodide. This mixture is considered to
be cathartic/cleansing or immune boosting. The preparation is used either
directly on the skin or drunk as a tonic. Patients are encouraged to avoid
pork, vinegar, tomatoes, carbonated drinks and alcohol, and to use immune
stimulants, yeast tablets, vitamin C, calcium, laxatives, and antiseptic
washes, as well as adopt a positive mental outlook while taking the Hoxsey
treatment.
Even though the American Medical Association admitted this treatment was
effective against some forms of cancer, the medical establishment branded
Hoxsey as the worst cancer quack of the century and forced his clinic to
Tijuana, Mexico, at the Bio-medical Center, where it continues to claim
very high success rates.
The idea is to stimulate the body's own defense system (the immune system)
to do what it usually does in a healthy body - overcome cancer. By supplying
the body with an overabundance of herbs and supporting this with various
digestive enzymes, iodine and potassium compound, the necessary nutrition
is provided. The herbal remedies are said to strengthen the immune system
and to help carry away wastes and toxins from the tumors that the herbal
compounds caused to necrotize. While this theory may be inexact, current
research appears to be vindicating Hoxsey, or at least showing that his
method merits a thorough, unbiased investigation by the medical orthodoxy.
The main component is its high concentration
of potassium iodide. While iodine itself does not have significant
anti-cancer properties, iodine is an important component of thyroid function,
and potassium is an important of cellular metabolism. The modern day diet
is generally low in potassium. Similarly, about 10 percent of the adult
population may have an under-active thyroid function that is considered
"normal" by traditional laboratory test. Supplementing with iodine will
ensure proper thyroid gland function.
The thyroid gland is the main temperature control center of the body. Those
with under active thyroids often will have a lowered basal body temperature.
Cancer cells cannot tolerate heat as well as normal cells due to the lack
of collateral circulation around tumor cells. Maintaining a normal temperature
creates an internal environment unfavorable for cancer growth.
Dose: The dose of the therapy varies, depending on the specific
needs of each patient and whether the cancer is internal or on the skin.
Some of the ingredients in the Hoxsey formula can cause side effects. For
instance, buckthorn bark can cause nausea, vomiting and diarrhea if taken
in large quantities. Cascara can cause diarrhea. Barberry root administered
to rabbits (dose unspecified) caused swelling of the kidney and cardiotoxicity.
5. Fish Oil. Over
half of all cancers are diet related, including breast and colon cancer.
A high fat diet rich in linolenic acid promotes
cancer and metastasis. Fish oil can inhibit metastasis. Fish oil contains
omega 3 (also present in flaxseed, walnut, cold water fish like salmon)
fatty acid.
Over the past 150 years, the ratio of omega 6 to omega 3 ratios has gone
from 2 to 1 to become 30 to 1. Omega 6 (corn and canola oil) fatty acid
is pro-inflammatory. Omega 3 is ant-inflammatory and acts like a natural
aspirin. Omega 3 blocks the arachondic acid cascade. Arachondic acid is
high in meat. Omega 3 and omega 6 compete for cell receptors and its incorporation
into the cell membrane. Omega 6 produces prostaglandin E2, which is associated
with reduced immune response, suppression of cytokines, attenuation of T-cell
proliferation, lower immune function, inhibition of macrophages and natural
killer cells, and promotion of tumor growth. Omega 6 supports angiogenesis
in many cancer tumors.
Fish oil has a direct effect on tumor cell proliferation via alternation
of prostaglandin E2 production. Fish oil directly inhibits tumor cell
proliferation and inhibits angiogenesis through inhibited VEGF, similar
to liquid shark cartilage. It also acts as counterbalance effect to omega
6 fatty acid's production of inflammatory econsinoids. Fish oil reduces
the rate of tumor attachment to endothelial extra-cellular matrix that leads
to angiogenesis. It also alters the rate of tumor attachment in lymph nodes.
Omega 3 reduces tumor promotion and metastasis with or without chemotherapeutic
agents. It has an adjunct therapy during chemo and radiotherapy. One
of the primary anti-cancer diets is to reduce fat intake to 20 percent (current
American Diet derives 40% of its calories from fat).
Dosage: Increasing intake of fatty
fish is the easiest. Most fish oil supplement provides 1500 mg
of fish oil, with about 450 mg of EPA and 300 mg of DHA per capsule. 6-9
capsules are needed per day. Flaxseed is a good source of omega 3 fatty
acid. It is better than flaxseed oil.
6. Mistletoe (Viscum album L.) is a semi-parasitic plant
that lives with several tree species, including oak, pine, fir, elm and
apple. It is found in Europe, America and Korea, but only the European
species is used in the treatment of cancer. Mistletoe (Iscador) has
long been used in the treatment of a variety of acute and chronic conditions.
It was not widely used for treating cancer, however, until the 1920s. Presently,
mistletoe is given to patients either as the central component of a complex,
broader treatment regimen in the practice of Anthroposophic medicine mainly
in Europe or as a single agent partially or completely removed from the
overall context of Anthroposophic care (e.g., in the United Kingdom and
other countries). It is widely used in Europe, at clinics and private practices
specializing in Anthroposophic or in various types of "holistic" medicine.
Its use in the United States is limited.
Mistletoe preparations are used to stimulate the immune
system and to kill cancer cells. Studies have shown that it reduces
tumor size and improves survival of some cancer patients. It
is particularly good for cancers of the cervix, ovaries, breast, stomach,
colon, and lung. In addition to treating solid tumors,
Iscador is also used, though less effective than on solid tumors, for cancers
of the bone marrow, connective tissue, and blood-forming organs, specifically,
lymphomas, sarcomas, and leukemias.
Therapeutic Dose: Mistletoe is typically given by subcutaneous
injection, ideally near the site of the tumor or indirectly into the
tumor, at the same time avoiding irradiated areas. Direct tumor injection
is most common for tumors of the liver, esophagus and cervix. A typical
treatment course lasts several months to years with subcutaneous injections
given early in the morning 3-7 times per week. The doses are gradually increased
and adjusted depending on the patient's general condition, sex, age, and
type of cancer. Side effects are rare, except rare cases of allergic
symptoms and an increase in body temperature and flu-like symptoms that
are desirable. The injection site can become inflamed and abdominal
pain with nausea may occur. Eating mistletoe, particularly the berries,
is considered highly toxic, especially for infants. Seizures and death have
been reported. Because the preparation contains tyramine, patients on
any type of monoamine oxidase (MAO) inhibitor antidepressant should not
take it. This product should only be used in a closely supervised setting,
and should not be used for normal consumption.
7. Medical Mushrooms
A. Maitake Mushroom: This Japanese mushroom is also called "hen of
the woods," because it grows in clusters that resemble the tail feathers
of a nesting hen. The most important studies on its effect on cancer cells
were carried out using nothing more than dried mushroom powder mixed into
animal feed. These studies showed that maitake mushrooms possessed the ability
to significantly inhibit various cancer systems when used orally. Like the
other mushrooms, Maitake's action is that of an HDP, or 'Host Defense Potentiator'.
The inhibition of tumor cells, in comparison to other mushrooms, appears
to be superior. Its main anti-cancer mechanism seems to be the activation
of the polysaccharide natural killer cells by the beta glucans present
in maitake. Maitake mushroom powder showed an 86% tumor inhibition in these
feeding studies. With similar activity was shiitake mushroom powder; an
inhibition rate of 78% was shown in the same study. The optimum dose in
animal experiments, performed by Dr. Hiroki Nanba of Japan, appears to be
25 mg./kg of body weight (about 1.5-2 grams
in adult) for cancer prevention and 3-4 times that much as adjuncts to conventional
treatment in powder form.
Maitake mushrooms can be analytically broken down into four different fractions
called Fractions A to D of active ingredients, with approximately 2.9 %
of fraction A, 0.59% of fraction B, 0.49% of fraction C, and 0.16% of fraction
D.
Out of the various fractions, studies seem to show that the
D-fraction is more potent against cancer cells. It has been shown
in vitro to reduce in vitro cancer cells mitosis by 91% versus 81% with
the maitake powder. Animal studies show tremendous effectiveness in tumor
growth inhibition (up to 98%) when maitake D fraction is used in combination
with half the usual dose of chemotherapy. A Japanese study did show extended
survival when maitake was used together with chemotherapy. It works well
orally to enhance natural killer cells, IL1. It is very important that D-fraction
is effective in oral administration, because any pure beta-glucan alone
is only effective through injection.
In another study of breast cancer and liver cell tumor, D fraction inhibits
the growth of breast cancer by 80% when given orally. When given at the
time of tumor implantation, the growth of cancer cells is reduced by 70
percent. Recurrence rate with maitake powder is 20% while the D-fraction
is only 10 percent. Its use is particularly useful in breast and lung cancer.
In vitro studies showed maitake extract leads to cell apoptosis in prostate
and breast cancer. In liver cancer, the combination of maitake D fraction
and chemotherapy is best. Early vitro cell line studies showed that in liver
cancer, D fraction, when combined with chemotherapy at half dose, yield
an effective rate of 96%. D fraction alone is 75%, while mitomycin C
is 46%. Breast and breast cancer- taking it alone or together with chemotherapy
- 75%
Therapeutic Dosage: 1 drop per kilogram
Maitake Pro-D fraction (1 drop contains 1 mg) and 2-8 grams whole mushroom
powder. There is a large variety of maitake mushroom powder on
the market, and the quality is very difficult to ascertain by the average
consumer. It is important to only buy from sources you can trust if
you take the raw powder form. Furthermore, mushroom powder
mostly contain hard
to digest fiber, and too high an intake may be cause a gastrointestinal
upset.
For safety and maximum effectiveness, it is best to take the standardized
extract form of maitake mushroom instead of maitake powder. Many
suppliers may not disclose the extraction ratio, but you should know or
its equivalent in extract form between meals or mushroom extract. A 100
mg. of 8:1 extract, for example, is equivalent to taking 800 mg. of dry
powder, even though the label only shows 100 mg. The higher the extraction
ratio, the less you have to take and still receive the desired active ingredient
and its effect. Good quality extracts run from a 4:1 to 8:1 extraction ratio and
is much more expansive than the powder form.
When used with 2000 mg of Vitamin C, the effect is synergistic and demonstrated
in breast and prostate cancer cell apoptosis, with a reduction based on
PSA marker.
Little information has been collected concerning the toxicity of maitake,
although some cases of allergic reactions have been reported. Maitake can
be found in gourmet restaurants, dried and packaged in gourmet grocery stores,
and increasingly in prepared products in the United States, Asia, and Europe.
As a general health supplement, 3 to 7 g a day in tea or in soups and other
dishes is recommended.
B.
Reishi Mushroom: Reishi (Ganoderma lucidum) has a dark, reddish-orange
cap. The Latin word lucidum means "shiny" or "brilliant", and refers to
the varnished surface of the Reishi cap. For four millennia, the Chinese
and Japanese have used Reishi as a medicine for liver disorders, hypertension,
and arthritis. Through in vitro and human studies, today's researchers have
found that Reishi has anti-allergenic, anti-inflammatory, anti-viral,
anti-bacterial, and antioxidant properties. In vitro experiments also indicate
that Reishi may help fight tumors. In addition, a protein isolated from
Reishi - Ling Zhi-8 - may reduce the risk of transplant rejection
Reishi is hard and bitter. You can buy Reishi dried and ground for tea,
but an alternative to the taste is in capsules. Reishi is an effective
immuno-stimulant that was demonstrated as an anti-tumor action. It
has been shown to protect the liver, act as a tonic for the central nervous
system and heart, lower cholesterol, and inhibit allergic response (histamine
release). Reishi has been shown to increase the production of Interleukin-1
& 2, is shown to be a significant anti-inflammatory, as well as inhibit
malignant tumor growth. It also is reported to reduce allergic responsiveness,
and protect the liver.
The active anti-cancer constituent in Reishi is called
Beta-D-glucan. Beta-D-glucan is a polysaccharide--basically
a huge sugar molecule made up of many little sugar molecules chained together
bound to amino acids. These intricate sugars stimulate or modulate the immune
system by activating immune cells such as macrophage and helper T-cells,
as well as increase the immunoglobulin levels (immunoglobulin are specific
types of antibodies) to produce a heightened response to foreign cells,
whether bacteria, viruses, or tumor cells.
One interesting and important finding by Dr. Fukumi Morishige, M.D., PhD,
the leading researcher in this field, was that the effectiveness of Reishi
could be increased by combining it with high doses of vitamin C. Polysaccharides
are huge molecules absorbed by the body with difficulty. Vitamin C aids
in the break down of these huge molecules into much smaller molecules called
oligoglucan, which can be easily absorbed. Vitamin
C, thus, increases the bioavailability of Reishi, and therefore, synergistically
increases Reishi's immune-stimulating and anti-cancer effects.
As the "medicine of kings", Reishi is widely used for different purposes.
It is used for symptomatic relief of arthritis, menopausal anxiety, asthma,
hypertension, hypothyroids, insomnia, and cardiovascular symptoms. Chinese medical texts traditionally call for using
1.5 to 9 grams of dry mushrooms per day, which approximates to 150 to 900
mg of concentrated Reishi extract. For serious illnesses like cancer, Dr
Morishige adjusts the dosage from 2 to 10 grams of Reishi per day.
Since it is almost impossible for the average consumer to ascertain the
quality of the Reishi powder, it is recommended that consumers buy powder
from only professional sources, or to take standardized extracts to ensure efficacy.
The extracts are usually more expansive.
C. Shitake - This Asian mushroom is medicinal as well as culinary.
Shitake contains cortinelin, a strong antibacterial agent. It also produces
an extract containing Lentinan, which stimulates the production of T
lymphocytes and natural killer cells. The reports show shiitake to take
positive action against several cancers and assists AZT in the treatment
of AIDS. These meaty and flavorful mushrooms contain a substance called
eritadenine that encourages body tissues to absorb cholesterol and lower
the amount circulating in the blood. You can find dried shiitakes at Asian
markets or at health food stores. This is a meaty and delicious mushroom
that can be used alone or as an ingredient in a variety of dishes.
Like maitake, shiitake also appears to be a formidable cancer fighter.
In 1969, scientists at Tokyo's National Center Research Institute isolated
a polysaccharide compound from shiitake they called lentinan. In laboratory
trials, lentinan caused tumors in mice to regress or vanish in 80 to 100%
of the subjects. Lentinan appears to stimulate immune-system cells to clear
the body of tumor cells. Taking shitake mushroom
in the standardized extract form is superior to the powder form, unless
the powder is from a reputable source.
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D. Agaricus Blazei Murill
(ABM) is one of the most potent of medical
mushrooms. It was first noticed about 30 years ago when two researchers
from Penn State University visited Piedade and discovered that the natives
were very healthy with very low rates of disease and that a disproportionately
high number enjoyed longevity. The polysaccharide contained in ABM vitalizes
production of interferon and interleukin. This effect indirectly functions
to destroy or prevent the proliferation of cancer cells. Researchers have
shown that ABM is effective against Ehrlich's ascites carcinoma, sigmoid
colonic cancer, ovarian cancer, breast cancer, lung cancer, and liver cancer,
as well as against solid cancer. In fact, in experiments performed on mice
injected with Sarcoma 180, a strong cancer-causing agent, that developed
cancerous tumors, ABM was found to be effective in 90% of all tested animals
in eliminating the cancerous tumors. ABM is
less promoted than the other mushrooms, but its therapeutic efficacy should
not be overlooked.
E. Cordycep Sinensis (CS) is a precious
tonic found in the high plateau of southwestern China at 3000-4000
meters above sea level. It is sometimes called caterpillar fungus, and comes
in the form of a fine light beige powder. In Chinese, Cordycep means "summer
plant, winter worm." Cordycep grow by infecting insect larvae or mature
insects with spores that germinate, often before the cocoon is formed. The
fruiting body of the Cordycep grows from the dead host. CS has been shown
by modern research to promote phagocytosis of peritoneal macrophages, enhance
the function of the reticuloendothelial system, and reduce cholesterol levels.
CS has been used in Chinese traditional medicine for over 1,000 years to
strengthen and rebuilt one's health after chronic illness and to treat lung
disease, impotence, and neurothenia and to restore renal functions. It is
an immune enhancer.
Recent studies have shown that CS is beneficial to
cardiovascular health, as well as immune, lung, kidney, and sexual functions.
It is an excellent tonic supplement overall for vitality and to counter
aging.
It is an excellent strengthening tonic for
convalescing patients, and patients with reduced appetite, weak blood, weakened
resistance of respiratory tract and susceptibility to colds or flu can take
this product orally to strengthen resistance.
Studies using CS have been confirmed, mostly conducted in China, with reported
effective rates of 78 percent to 94.2 percent in the treatment of malignant
cancers, bronchitis, heart diseases, leukemia, lung diseases, cirrhosis,
B hepatitis, and diabetes.
The active polysaccharide in Reishi mushrooms
varies from 5-25% by weight. Choosing the right powder is almost impossible
for the average consumer. Always buy from a reputable and professional source.
Dosage: 1-3 grams a day. High quality natural CS can cost over $1,000
per pound due to its scarcity. However, recently developed cultured CS using
bioengineering processes have significantly lowered the cost and increased
its availability to consumers. The best method
is to take standardized CS extract with a 2:1 extract ratio and at least
20% active ingredient (polysaccharide) by content. A 350 mg 2:1
extract capsule will therefore yield an equivalent of a 700 mg CS powder
capsule. 20% of active ingredients of such a capsule will yield about 140
mg of polysaccharide. Normal dosage is 1 to 2 tablets per day. Take 2-3
times more for therapeutic dose.
What you should know about medical mushrooms: Medical mushrooms
are well known immune system enhancers. They have been used for centuries
as a tonic and folk medicine for a variety of other diseases. Intensive
research is on going, but it is evident that each has its own special anti-cancer
properties. For anti-tumor activity, Maitake,
Reishi, Shitake, and Agaricus are good choices. Cordycep is the preferred
choice as a strengthening tonic specially suited for convalescing patients.
There is no one "magic" mushroom. Taking it as a blend or mushroom "cocktail"
makes the most sense for most patients.
| Attention Because of tremendous individual variation, the use of nutritionals should therefore be personalized for your body. One person’s nutrient can be another person’s toxin. If you have a specific health concern and wish my personalized nutritional recommendation, write to me by clicking here. |
8. Bovine Tracheal Cartilage (BTC):
BTC has been used since the early fifties and has been effectively used
to treat many conditions including cancers, tumors and arthritis ever since.
It is considered to be a non-toxic material has been scientifically demonstrated
to produce anti-mitotic, anti-angiogenic and anti-inflammatory activities.
It was developed by Dr. John Prudden, a Harvard trained physician. Dr. Prudden
published a 31 patient case series in which he recorded some remarkable
remissions in a wide variety of intractable malignancies including, but
by no means limited to, Pancreatic Cancer, Metastatic Breast Cancer, and
Glioblastoma Multiforme. Some of these patients had been followed for more
than five years at the time the case series was published in 1985. Out of
the 31 cancer patients that had been treated, the response rate was 90 percent.
Sixty-one percent had complete remission of tumors. Both oral and injected
forms were used, but the oral was somewhat better.
In 1994, a group not associated with Dr. Prudden, published an abstract
reporting a clinical trial of BTC in 35 patients with Metastatic Renal Cell
Carcinoma. Within 3 months, 22 of the 35 patients had completed therapy
and there were three objective responses, none of which had relapsed with
follow-up of 6+, 12+, and 30+ months. There were also two patients with
stable disease. While the response rate here is not as good as that reported
by Dr. Prudden himself, independent confirmation of anti-cancer activity
of a non-toxic alternative treatment is reassuring.
The main mechanism of action is immune modulation by polysaccharide components
of BTC, although there may also be a direct cytostatic effect as well. There
is well-documented evidence that oral polysaccharides
can have an immune modulatory and anti-tumor effect in humans. Such
polysaccharides are also present in Maitake mushroom, for example. This
mechanism of action is very different from that of shark cartilage, which
is known for its anti-angiogenic factors.
Dose: 3 to 5 grams per day of powder in the form of capsules before
meals. The cost is much less than shark cartilage. Responses may take
several months to develop, and if there is a response, treatment should
be continued indefinitely. Side effects associated with BTC therapy
is limited and generally mild, including gastric upset, fatigue, nausea,
fever, dizziness, and edema of the scrotum. It is virtually non-toxic.
9. Ukrain - Ukrain was first developed
in 1978 by Dr. Wassyl J. Nowicky, director of the Ukrain Anti-Cancer Institute
of Vienna, Austria and unveiled at the 13th International Congress of Chemotherapy
in Vienna in August 1983. It is classified as a semi synthetic "reaction
product" or "conjugate" created by the merger of a common herb, Greater
Celandine (Chelidonium majus L.) and one of the oldest cytotoxic drugs,
thiotepa.
Greater Celandine is a poppy-like plant, filled with a bright and acrid
orange-colored juice. It has a long folk history of disease-fighting effects.
A tincture, or lower attenuations, is used in homeopathy, mainly as a liver
remedy. The main ingredients of this plant are alkaloids, such as chelidonine,
which have anticancer potential. By analogy, the common periwinkle contain
alkaloids and yield two standard anticancer agents, Vinblastine and Vincristine.
Such alkaloids, taken by themselves, can be irritating or even toxic.
The force marriage of this herb and the thiotepa drug results in a compound
that is non-toxic to normal cells, yet has a strong affinity for killing
cancer cells. Animal studies in hamsters and rats, for example, showed
no clinical signs of toxicity or damage to embryos. The only toxicity was
a slight decrease in the average hamster's litter size. In addition, for
three years, healthy human volunteers in Poland, Austria, and Germany, received
repeated courses of the new drug with few side effects; other than some
local pain, and a few reported cases of drowsiness, as well as increased
thirst and urges to urinate.
Ukrain has been tested extensively against 60 different human cancer cell
lines at the National Cancer Institute with a 100 percent growth inhibition.
While the exact mechanism is not known, it apparently increases the oxygen
consumption of both normal and malignant cells; but while oxygen consumption
normalizes in non-cancerous cells within 15 minutes, it decreases irreversibly
to zero in cancer cells, effectively killing them.
In addition, Ukrain activates a whole series of highly effective immune
system mechanisms in the patient so that the body's own antitoxins contribute
towards combating the tumor. It also has anti-angiogenesis properties. This
results not only in the "starvation" of the tumors but also suppression
of metastases formation. It was found to be cytostatic or cytotoxic to human
leukemias, large and small cell lung cancers, colon cancers, central nervous
system cancer, melanomas, ovarian cancer and renal cancer.
In the clinical trial, the drug was given either intramuscularly or intravenously
either every day or every second to fifth day, for ten days to three months.
There was some slight transient pain reported on intramuscular injections.
In general, patients who had a weak response to Ukrain also experienced
little heat or pain in the tumor sites. The cost is quite high. Ukrain is
only available through holistic clinics mainly in Europe, Mexico, and selected
clinics in USA and is quite expensive.
10. Additional factors to boost immunity:
a. Avoid chemotherapy and radiotherapy,
which suppress the rapid turnover over in immune cells
b. Avoid immune lowering drugs
such as glucocorticoids, commonly prescribed for
asthma and other inflammatory conditions
c. Get the proper amounts of sleep, along with adequate
exercise and stress reduction. This will normalize the adrenal gland and
reduce production of internal cortisol, an anti-inflammatory and pro-aging
hormone
d.
Moderate alcohol intake.
e. Proper nutrition and diet. Supplement
with vitamins A, C, E, B6 and folic acid. Moderate supplementation with
zinc, chromium, magnesium, and selenium is also recommended
f. Additional supplementation such as amino acid glutamine, herbs such as Echinacea and goldenseal,
as well as thymus extract can help to support normal lymphocyte
proliferation and maintain dysfunctional immune system.
Summary:
Maintaining a strong immune system
is a key component to any anti-cancer program. A variety of micronutrients
are available to achieve this. Taking a blended cocktail of the above immune
enhancing nutrients should be considered for cancer prevention and cancer
treatment.
| Message from Dr. Lam I hope you have enjoyed reading this article. If you have areas you don’t understand, comments (good or bad), or if you have a specific health concern, feel free to write to me by clicking here. |
Michael Lam, M.D., M.P.H., A.B.A.A.M. is a specialist in Preventive and Anti-Aging Medicine. He is currently the Director of Medical Education at the Academy of Anti-Aging Research, U.S.A. He received his Bachelor of Science degree from Oregon State University, and his Doctor of Medicine degree from Loma Linda University School of Medicine, California. He also holds a Masters of Public Health degree and is Board Certification in Anti-aging Medicine by the American Board of Anti-Aging Medicine. Dr. Lam pioneered the formulation of the three clinical phases of aging as well as the concept of diagnosis and treatment of sub-clinical age related degenerative diseases to deter the aging process. Dr. Lam has been published extensively in this field. He is the author of The Five Proven Secrets to Longevity (available on-line). He also serves as editor of the Journal of Anti-Aging Research.
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at www.LamMD.com. Feel free to email
Dr. Lam at dr@LamMD.com if you have any questions.
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