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  •  Cancer Prevention | Page: 1
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Reading Tips:

For fast reading, scan through the topic headings in BOLD BLACK, important conclusions in BOLD BLUE, and "Must Know" in BOLD RED. To jump to specific sections in this article, click on the respective LINKS in the Table of Contents.

Information presented here is for general educational purposes only. Each one of us is biochemically and metabolically different. If you have a specific health concern and wish my personalized nutritional recommendation, write to me by clicking here.

Cancer Prevention

Michael Lam, MD, MPH
www.DrLam.com

Introduction

The events leading up to cancers often take place long prior to the clinical detection of the disease. It is a disease skewed towards old age. The median age of a U.S. cancer patient is 70. According to the National Cancer Institute, the odds of getting cancer after age 60 is 16 times greater than before age 40.

Cells in our body are dividing 24 hours a day. Bad mutations are few, but they do happen. When enough mutations have occurred, the result can be cancer. In fact, we are all walking around with millions of pre-malignant cells. If we live long enough, we will come down with one form of cancer or another. Advancements in technology have increased life expectancy in industrialized nations to almost 76 years. Cancer is quickly replacing cardiovascular disease as the number one cause of death in the United States.

The lifetime chance of getting cancer of the colon is 6%, prostate 17%, breast 14%, and lung 7%. At the same time, proper diet, supplementation, and lifestyle changes can reduce cancer of the colon by up to 50%, prostrate by15%, and lung by 90%. Dr. Gabriel Deldman, Director of the American Cancer Society, sums it up well by saying, "We don't need years of research. If people implement what we know today, cancer rates would drop. It's that simple."

Unfortunately, cancer chemoprevention research is 10-15 years behind cancer treatment research. It makes more sense to treat pre-cancerous lesions than to wait for people to develop fully blown cancer.


How Cancer Develops

We now know that cancer cells are developed in 3 phases:

  1. Initiation (Phase 1): When something (such as a free radical or carcinogen) alters a cell's genetic makeup, causing the cell to divide more frequently than it should. 
  2. Promotion (Phase 2): When the damaged cell goes into uncontrolled growth.
  3. Progression (Phase 3): When the tumor builds itself a blood supply network through angiogenesis and invades surrounding tissue.
The cornerstone of cancer prevention research is to design drugs that thwart the carcinogenic process at points where mutations may occur. One goal is to find drugs that limit the damage caused by substances which cause cell mutations. These substances include such things as tobacco smoke, environmental pollutants, or even toxic substances we may eat - such as nitrosamines, in bacon and cured meats, to pesticide residues, in fruits and vegetables. Another goal is to use gene therapy to stop the random genetic mutation that results in cancer. A third goal is to intercept "free radicals" and errant oxygen molecules that are released during normal cellular metabolism (production of ATP) in order to prevent the damage they can do to cells and to trigger genetic mutations.

One trillion molecules of oxygen go through each cell every day, inflicting about 100,000 free radical wounds on the DNA. By age 30, a few million free radical lesions per cell exist in each of our body's cell. By age 50, about 30% of our cellular protein has been damaged by free radicals. The solution is to fight the free radicals with antioxidants such as selenium, beta-carotene, vitamin E, and vitamin C, among others. 


Markers of Cancer

Unlike cardiovascular disease where established markers such as cholesterol have a clear correlation with the disease, many markers associated with pre-cancerous lesions have yet to be validated. There are only a few screening tests for cancer, like the Pap smear for uterine cancer and prostate surface antigen (psa) for prostate cancer. Until we get better imaging technology, determine markers, and develop preventive drugs, we are left with few precious markers for the early detection of many cancers. 


  •  Cancer Prevention | Page: 1
  • Continue Reading... 1 | 2 | 3 | 4 | 5 | Next