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New Protein Possible Way To Treat Cancer

Researchers may have found a new way to battle cancer by disturbing the balance of cells within a tumor. Researchers have discovered differences in tumor cells found in different regions of the body. For example, regions rich in oxygen have cancer cells different than cells found in regions deprived of oxygen.

This difference is due to the various ways each cell is able to fuel itself. Well oxygenated tumor cells have been discovered to use lactate instead of glucose, as previously thought. Lactate is obtained as a waste product from hypoxic cells, which use glucose as their main source of energy. Researchers believe that the complementary relationship between the 2 cells helps the tumor survive.

Researchers were able to decrease tumor growth by upsetting this relationship. They did this by blocking the protein MCT1. MCT1 is the protein that allows cells to take up lactate. By not taking up lactate, well oxygenated cells switch to glucose as their main source of energy. This then deprives the hypoxic cells of their energy source. Researchers hope that the MCT1 protein can be a new target for anticancer therapies.

SOURCES: The Journal of Clinical Investigation, Nov. 20, 2008




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