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Death Triggered by Acne Cream

A new study shows that patients who use acne creams with the ingredient retinoid tretinoin are more likely to die than those who do not.

In 1998, the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial decided to test if a cream containing retinoid tretinoin could prevent cancer. About a thousand 70+ men were told to put on either an unmedicated cream or a cream containing 0.1% tretinoin daily to their face. Over six months, dermatologists examined them.

However, a preliminary account illuminating a raise in death count among the men using tretinoin stopped the test six months early. Upon investigating other reasons that might have amplified the risk of death, including age, smoking and co-occurring illnesses, there was still a notably higher threat of death in the treatment faction. Yet, tretinoin could not be confirmed as being the major cause of the losses.

SOURCE: Archives of Dermatology, 2009;145[1]:18-24


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