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Lipoprotein (a) - How To Reduce
By: Michael Lam, MD, MPH
www.DrLam.com
Lipoprotein A, commonly called Lp(a), is a major independent risk factor for cardiovascular disease. The optimum laboratory level should be under 20 mg/dl and preferrably under 14 mg/dl.

Currently, there are no medications or drugs that can effectively lower your Lp(a). A high Lp(a) is genetically linked.  

Fortunately, Mother Nature has provided us a much better non-toxic alternative. It consist of large doses of vitamin C, L-lysine, and L-proline. Vitamin C, L-Lysine and L-proline are the basic building blocks of collagen. When these vitamins enter our bodies, they form collagen in large amounts. This is necessary, as collagen must be replenished in blood vessels to remain healthy and plaque free over periods of time. The reason is simple - Lp(a) is manufacturered in the liver in response to aging vascular system and "micro-fissures" in the endothelial vascular wall. The body, in its attempt to patch up these fissures, produce cholesterol and its relative Lp(a).
Unfortunately, Both cholesterol and Lp(a) are sticky , making them perfect for the job.

Lp(a) is many times more potent than cholesterol in its patching ability and has a tendency to attract other Lp(a) particles. The aggregation of Lp(a) forms a plaque that leads to vascular occlusion.

This mega vitamin cocktail therapy will increase blood concentrations of important substances and focuses on:

  • Strengthen and heal blood vessels
  • Lower LP(a) blood levels
  • Inhibit the binding of LP(a) molecules in the walls of blood vessels

Only a few animals do not produce their own vitamin C, and humans are one of them. Vitamin C must therefore be taken from external source.

From our Readers

Dr. Lam,
Thank you for showing me how to significantly reduce my cardiovascular risk. Through your coaching I have been able to reduce my LP(a) level by 50%!

With my family heart history, I have been dilligent about seeing my cardiologist. When my blood test showed a exceptionally high LP(a) level and my cardiologist did not know how to reduce it and told me not to worry about it - I got concerned. I did my own research and found that I should be worried about it - thats when I found you.

My LP(a) levels have come down significantly just as you said was possible during our first phone call almost one year ago. I am looking forward to continuing to reduce my LP(a) and now Homocysteine levels as we discussed. Thank you for the great work!

Kent, CA

The amount varies between individuals and depends on the individual's health condition. Heart patients with serious conditions require more than normal individuals with high Lp(a).

In addition to the above triple cocktail (vitamin C, L-lysine, and L-proline), other foundational nutrients are important to enhance vascular wall function. These include vitamin E and L-carnitine, a natural compound stimulating fatty acid oxidation in the mitochondria. To further enhance the effectiveness of the cocktail, it is important to use bioflavonoids and ascobyl palmitate . Many conventionally trained physician uses niacin to reduce Lp(a). This does work to a limited extend. Niacin reduces the production of lipoprotein A in the liver, and helps to bring down the lipoprotein A in the blood. This is what most conventional doctors use. However, this approach has its limitations because until the endothelial wall is optimized and cleared, the lipoprotein A level will not be able to reduce significantly. The effects of niacin usually hit a plateau after 6-9 months of therapy. If you are on niacin, make sure the liver enzyme levels are taken periodically to make sure the liver is able to handle the high dose of the niacin.

Vitamin C is water-soluble. A large amount is needed in order to reach adequate blood and tissue concentration. The amount of ascorbic acid can be reduced if ascobyl palmitate, the fat-soluble form of ascorbic acid, is used at the same time. This combination is also more effective, as it allows vitamin C can stay in the body much longer.

Improvements on LP(a) level can usually be seen within weeks to months for the majority of the people. The higher the starting value, the more significant was the reduction. Lp (a) can be completely normalized and bought to optimum level of under 14 mg/dl on nutritional therapies alone if treated properly. Unfortunately, not all people show positive signs of reduction. Some people are particularly resistant, and may take upwards of 1 year to effect minor change. In a small group or people, no change at all can be expected. All people with high Lp(a) should be started on a nutritional cocktail. Even if repeat the blood level does not show any improvement, vascular integrity is enhanced. There is nothing to loose and everything to gain.



For those who are unfamiliar with Lp(a), here are some articles on this subject:

RESEARCH ARTICLES ON LP(A)

Angles-Cano ; Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process. Braz J Med Biol Res 1997 Nov;30(11):1271-80.

Lipoprotein Lp(a) is a major and independent genetic risk factor for atherosclerosis and cardiovascular disease. It is relative of LDL or bad cholesterol The difference between Lp(a) and low density lipoproteins (LDL) is apolipoprotein apo(a), a glycoprotein structurally similar to plasminogen, the precursor of plasmin, the fibrinolytic enzyme.

Lp(a) has the capacity to bind, fibrin and membrane proteins of endothelial cells and monocytes. It also stops plasminogen binding and plasmin generation. The inhibition of plasmin generation and the accumulation of Lp(a) on the surface of fibrin and cell membranes favor fibrin and cholesterol deposition at sites of vascular injury.


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Price KD; Price CS; Reynolds RD; Hyperglycemia-induced latent scurvy and atherosclerosis: the scorbutic-metaplasia hypothesis. Med Hypotheses 1996 Feb;46(2):119-29.

Latent scurvy is characterized by a reversible atherosclerosis that closely resembles the clinical form of the disease.

Acute scurvy is characterized by microvascular complications such as widespread capillary hemorrhaging. Vitamin C (ascorbate) is required for the synthesis of collagen, the protein that is most critical in the maintenance of vascular integrity.

In latent scurvy, it has been suggested that large blood vessels use modified LDL, in particular lipoprotein(a) and collagen to maintain macrovascular integrity. This is because collagen will be spared for the maintenance of capillaries, the sites of gas and nutrient exchange.

The foam-cell phenotype of atherosclerosis is identified as a mesenchymal genetic program, regulated by the availability of ascorbate. When vitamin C is limited, foam cells develop and induce oxidative modification of LDL. This stabilizing large blood vessels via the deposition of LDL. The structural similarity between vitamin C and glucose suggests that hyperglycemia will inhibit cellular uptake of ascorbate, inducing local vitamin C deficiency.



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Chong PH; Bachenheimer BS Current, new and future treatments in dyslipidaemia and atherosclerosis. Drugs 2000 Jul;60(1):55-93.

Nicotinic acid has been made tolerable with sustained-release formulations, and is still considered an excellent choice in elevating HDL cholesterol. It is also potentially effective in reducing lipoprotein(a) [Lp(a)] levels.

Although LDL cholesterol is still the major target for therapy, it is likely that in future, other lipid/lipoprotein and nonlipid parameters will also become targets for specific therapeutic interventions. Other significant lipid/lipoprotein parameters that have been associated with CHD include elevated triglyceride, oxidized LDL cholesterol and Lp(a) levels, elevated C Reactive Protein, elevated homocysteine, and low HDL levels.

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About The Author

Michael Lam, M.D., M.P.H., A.B.A.A.M., is a western trained physician specializing in nutritional and anti-aging medicine. Dr. Lam received his Bachelor of Science degree from Oregon State University, and his Doctor of Medicine degree from the Loma Linda University School of Medicine in California. He also holds a Master’s degree in Public Health. He is board certified by the American Board of Anti-Aging Medicine where he has also served as a board examiner. Dr. Lam is a pioneer in using nontoxic, natural compounds to promote the healing of many age-related degenerative conditions. He utilizes optimum blends of nutritional supplementation that manipulate food, vitamins, natural hormones, herbs, enzymes, and minerals into specific protocols to rejuvenate cellular function.

Dr. Lam was first to coin the term, ovarian-adrenal-thyroid (OAT) hormone axis, and to describe its imbalances. He was first to scientifically tie in Adrenal Fatigue Syndrome (AFS) as part of the overall neuroendocrine stress response continuum of the body. He systematized the clinical significance and coined the various phases of Adrenal Exhaustion. He has written five books: Adrenal Fatigue Syndrome - Reclaim Your Energy and Vitality with Clinically Proven Natural Programs, The Five Proven Secrets to Longevity, Beating Cancer with Natural Medicine (Free PDF version), How to Stay Young and Live Longer, and Estrogen Dominance. In 2001, Dr. Lam established www.DrLam.com as a free, educational website on evidence-based alternative medicine for the public and for health professionals. It featured the world’s most comprehensive library on AFS. Provided free as a public service, he has answered countless questions through the website on alternative health and AFS. His personal, telephone-based nutritional coaching services have enabled many around the world to regain control of their health using natural therapies.

 
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