Dr. Lam Author of
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Grapefruit
Michael Lam, MD, MPH
www.DrLam.com
 Citrus
fruits are an important part of a good diet because they provide vitamin
C and other essential nutrients. There is approximately 65 mg of vitamin C and 250 mg of potassium
in an orange. Grapefruit contain high levels of a flavonoid ( plant
compound) called naringin. This
substance reduces the activity of a group of P450 enzymes known as CYP3A
enzymes. Your body uses these enzymes to break down certain drugs, such
as calcium channel blockers ( commonly used in the treatment of high
blood pressure), sedatives, and cyclosporine ( an immune suppressant
given to people who have received organ transplants). If you eat a lot of
grapefruit, the naringin may inhibit the action of these enzymes. The drugs,
if taken concurrently, are not metabolized. They remain in the body in
concentrations higher than normal. This increases
the risk of unwanted toxic effects.
If you are taking prescription medication,
ask your physician if you should avoid eating  grapefruit
or grapefruit juice. Certain drugs, like cyclosporine, already
carry a warning.
The good news is that there are plenty of substitutes. Orange, tangerines,
and tangelos have plenty of anti-oxidants but very low levels of naringin.
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About The Author
Michael Lam, M.D., M.P.H., A.B.A.A.M. is a specialist in Preventive and Anti-Aging Medicine. He received his Bachelor of Science degree from Oregon State University, and his Doctor of Medicine degree from Loma Linda University School of Medicine, California. He also holds a Masters of Public Health degree and is Board Certification in Anti-aging Medicine by the American Board of Anti-Aging Medicine. He has authored numerous articles and the following books: The Five Proven Secrets to Longevity, How to Stay Young and Live Longer, Estrogen Dominance - Hormonal Imbalance of the 21st Century, and Beating Cancer with Natural Medicine.
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© 1999-2009 Michael
Lam, M.D. All Rights Reserved.
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