Is it more important to measure DHEA-S or DHEA in measuring DHEA levels
Q: Is it more important to measure DHEA-S or DHEA in measuring DHEA levels – I am confused by this? My blood DHEA-S level is normal (148 on a scale of 48-247) – my saliva DHEA level is low (2) on a scale of 3-10. Should I retest with the saliva using the DHEA-S test (or is the DHEA sufficient) before considering supplementation with either or both DHEA and Pregnenolone?
A: DHEA itself cannot be measured easily as a hormone. All DHEA, blood or saliva, is measured by the bounded sulfate form which is called DHEA-S. The blood DHEA-S measures the bound fraction and is an approximate level of the DHEA in your body. The saliva measures the free fraction and the DHEA which is bioactive and available to the cell. Conventional physicians do not believe in saliva test because they are not educated in this area. If you really study the picture, saliva test for hormones is much more accurate in my view. Furthermore, DHEA test should be viewed together in conjunction with saliva cortisol as an indication of adrenal stress profile. Supplementing DHEA for the sake of low DHEA is seldom a long term solution unless the underlying adrenal dysfunction (as indicated by cortisol test and cortisol to dhea ratio) is rebalanced if cortisol is imbalance. Read the following: https://www.drlam.com/adrenal-fatigue/adrenal-fatigue-syndrome/fundamentals-adrenal-fatigue/