MTHFR & Adrenal Fatigue Syndrome

By: Michael Lam, MD, MPH; Justin Lam, ABAAHP, FMNM

MTHFR could be the reason for many illnesses in your bodyMethyl-tetrahydrofolate reductase (MTHFR), is an enzyme that is responsible for methylation in every single cell in your body. If you have a history of multiple miscarriages, chronic migraines, irritable bowel syndrome, depression, or a family history of heart attack or stroke, this little enzyme might be the cause of your illness.

Methylation 101

MTHFR’s function in your body is to methylate your cells, but what is this exactly and how does it work? Methylation is the process of adding a methyl group, one carbon and three hydrogens, to a compound. By doing so, MTHFR can help create, convert, and alter compounds within your cells. Methylation has its hands in many processes. It is involved in cellular repair, where it plays a major role in the synthesis of nucleic acids and the production of DNA and mRNA. It helps with neurotransmitter production and detoxification by converting amino acids from one form to another. It is vital in the formation and development of red blood cells, white blood cells, platelets, and the maintenance of a healthy immune system.

MTHFR has more than fifty variants; the most common are 677T, 1298C, or a combination of both.

Some of these variants cause a decrease in methylation, and as a result, can lead to disease. For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia. Conditions associated with variant 1298C include fibromyalgia, chronic fatigue, schizophrenia, chronic migraines, and irritable bowel syndrome.

MTHFR can be either heterozygous or homozygous. People with a heterozygous MTHFR have one normal gene and one altered gene. This will cause your enzyme activity to decrease by forty percent.

If you are homozygous, meaning both your MTHFR genes are anomalies, your enzyme activity can drop by as much as ninety percent and your system will only be methylating at a rate of ten percent to twenty percent of normal.

Aggravating factors for MTHFR include heavy metals exposure from amalgam, vaccines, mercury laced fish, aluminum cookware and occupational hazards as well as a diet high in processed and hydrogenated foods. Anesthesia, diabetes, lymphoma can also be factors that aggravate MTHFR.

MTHFR sufferers also in general have problems clearing metals, including lead, mercury and aluminum. This is due to the body’s inability to clear toxins on a timely basis. Symptoms seem to progress with time.

Screening for MTHFR Mutations

If you fall under any of the following categories, screening for potential MTHFR mutation may be considered.

  • Patients suffering from several mental conditions such as depression, anxiety, schizophrenia.
  • Relatives of someone with known MTHFR mutations.
  • Increased folate, homocysteine, cobalamin levels for no apparent reason.
  • Patients with severe neurological disorders such as multiple sclerosis, epilepsy, autism, or Alzheimer’s disease.
  • Strong family history of heart disease and stroke.
  • Infertility.
  • Patients with birth defects.
  • Drug sensitivities to anesthesia, nitrous oxide, methotrexate.

Laboratory Testing for MTHFR

Testing for MTHFRA blood test can include common laboratory serum tests such as liver enzymes, ferritin and homocysteine levels. The genetic testing can include the MTHFR profile. Glutathione is usually found low. The B12 level may be high, because the body is unable to utilize the unmethylated form. A urine analysis can be helpful; it may show heavy metal challenges to be positive and urine organic acid may be present. A Toxic Screening test may show excessive amounts of toxins present.

MTHFR Treatment

Just because you have the mutation does not mean you will show symptoms or develop conditions associated with MTHFR. Not all MTHFR sufferers need to be treated. Many have a marginal expression of MTHFR and lead a normal life.

If you learn that you do have significant MTHFR variants that are symptomatic, supplementation with the activated form of folate (vitamin B9) and B12, also known as methylfolate and methylcobalamin respectively, is recommended.

Methylcobalamin, more commonly referred to as vitamin B12, is naturally found in foods such as meat, seafood, and dairy products. As long as the dosage is properly titrated methylated vitamin B12 is safe for most people and may be taken as a nutritional supplement. Methyl B12 is best taken as an intramuscular shot, nasal spray, or sublingually in high doses.

Excessive vitamin B12 supplementation can cause anxiety, jitters, rapid heart rate, heart palpitation, and fatigue. Most of these side effects are mild, but medical evaluation is recommended because some of the possible side effects can be serious and should only be treated under supervision. Each person requires specific nutrients tailored to his or her own body and titration is necessary to obtain the optimal dosage with minimal side effects.

Methyl folate is taken orally. Physician supervision is best as the dosage needed is high. Methylfolate side effects include: severe anxiety, irritability, palpitations, acne, rash, sore muscles, achy joints, insomnia, nausea, headaches, and migraines.

On top of oral supplementation, prescription medications are also available. Drugs such as MetanX, Deplin, and CerefolinNAC contain methylfolate and may be beneficial.

Treatment of MTHFR also needs to be directed towards toxin control if the body is strong enough to handle it. This is important because the body’s toxic load and toxin clearance capability is reduced. Household chemicals, such as artificial scents, cleaners, and pesticides should be avoided. Chronic chemical exposure should be curtailed as much as possible. Use safe chemicals and organic pest control chemicals whenever possible.

From a diet perspective, it is important to avoid hydrogenated fats and processed foods. Increased consumption of fruits and vegetables are vital to alkalize the body and help the liver metabolize normally.

MTHFR and Glutathione

MTHFR and GlutathioneOne reason that MTHFR variants are linked to a variety of illnesses is their common pathway and connection to glutathione production. Glutathione is the body’s main detoxifying agent and intracellular antioxidant. Glutathione is also called the master recycler as it recycles other vitamins such as vitamin C and E. People with MTHFR anomalies typically present with lower levels of glutathione. This makes them more susceptible to toxins, which can lead to liver congestion.

Supplementation of glutathione is therefore very important in all suspected MTHFR conditions. Since oral glutathione is poorly absorbed, a liposomal form using nanotechnology is recommended. N-acetylcysteine (NAC) or alpha lipoic acid may also be taken, but they are not very effective.

In many cases where MTHFR is mild, oral glutathione supplementation alone is sufficient to effect dramatic improvement. This is particularly relevant to those who are weak or when methylated B12 or methylated folate may be too strong a therapy to be considered.

Adjunct Therapy

In terms of supplementation, adjunct supplements can be helpful provided that the body is healthy and strong. These include methyl donors (such as DMG, TMG, betaine), fatty acids to help reduce inflammation (such as fish oil, flax seed), minerals (such as zinc, magnesium), herbs that support liver detoxification (such as milk thistle), vitamin C, and amino acids. They do not apply to those with advanced Adrenal Fatigue Syndrome (AFS).


AFS represents the neuroendocrine deregulation of the body under excessive physical and emotional stress. Common symptoms include fatigue, insomnia, and lethargy. Symptoms in advanced stages can include hypoglycemia, heart palpitation, depression, anxiety and loss of libido. Sufferers usually have a wide variety of non-specific complaints that seem to defy conventional medical wisdom because laboratory tests are usually totally normal.

It is unknown whether MTHFR is associated with AFS or not. If it is indeed associated the degree of correlation is also unknown. Much more research is necessary.

Due to the concurrent hypersensitivity of AFS sufferers to nutritional supplementation, paradoxical reactions can occur frequently. The use of methylated folate and B12 for MTHFR should proceed with care. Those that have mild AFS with moderate symptoms can have a trial of this supplementation under proper supervision. If MTHFR variant is indeed the culprit, relatively quick resolution and improvement of symptoms is expected. The failure of significant improvement is an alert that MTHFR may not be the dominant cause of fatigue even if MTHFR testing is positive. Over aggressive use of methylated folate and methylated B12 is a common recovery mistake in those with AFS as they can mask the underlying problem and worsen AFS. Energy output may be up, but the underlying adrenal weakness is overlooked.

Those with advanced stages of AFS need to be very cautious because they usually fare quite differently. Because of their already highly sensitized bodies and low threshold of stimulatory excitation response, any product including methylated folate or methylated B12 can further increase an excitation response and trigger an adrenal crash. The more advanced the AFS the higher the risk. Using such compounds should only proceed under the guidance of a health care professional.

A frustrated man that may have MTHFRAlternatively, a much gentler way to approach MTHFR deregulation if suspected in both mild and severe AFS cases is to use liposomal glutathione to start. Glutathione is part of the pathway of many methylation enzymatic responses. As mentioned earlier, most MTHFR sufferers are found to have low glutathione. Supplementing with glutathione therefore is a direct and gentle way to overcome MTHFR without causing excitation and unintended negative consequences.

Glutathione through its direct supply into the body, have the additional benefit of helping the liver to detoxify. It therefore has direct and indirect benefits. To put it simply, glutathione helps the body methylation process without being overly aggressive. We believe that this is a much gentler first step approach. Methylated B12 and methylated folate can be added if and when the body is strong and stable.

© Copyright 2014 Michael Lam, M.D. All Rights Reserved.

MTHFR could be the reason for many illnesses in your body
5 - "Thank you so much"
Thank you so much for all of your help, Dr. Lam! You are amazing! I am going to read everything you recommended to me! I really appreciate you taking the time to help me! I will be in touch!


  • Heather Rozelle says:

    I have been diagnosed as compound heterozygous mthfr. I was put on a compounded methylated b vit that includes zinc, magnesium, acetylcysteine, and d3. A later neurologist doing more testing found my ferritin and iron saturation levels to be very low. He put me on a 325mg iron twice a day, five months ago. And I eat various animal proteins regularly. Is there something that keeps my from absorbing my iron? Could this be caused by my mthfr? I’m so tired all the time. Even my muscles are tired. Any help would be greatly appreciated.

  • AJ says:

    I see you mention methyl folate and methylated B12, but are there any specific supplements you would recommend?

    • Dr.Lam says:

      You need to be very careful not to overdo methylation when AFS is present. We generally wait until the AFS is well healed as condition precedent because the wrong timing can worsen the AFS and trigger crashes.

      Dr. Lam

  • Charmaine says:

    If one is not able to methylate, how can you properly detox the body that is already super sensitive from adrenal issues?

    • Dr.Lam says:

      That is a good question. It can be done in most cases because the body is not absolute. Takes a lot of experience and everyone is different.

      Dr. Lam

  • Jed says:

    I’m very sensitive to the methyl folate and methyl b12. My side effects are brain fog and severe anxiety after just a few days of taking them. Would you recommend starting slowly with one over the other first? Or do these symptoms subside eventually? Thank you!

    • Dr.Lam says:

      In many cases with people who are in AFS, the treatment for MTHFR makes them worse. You need to focus on the AFS. You also need to be very careful.

      Dr. Lam

  • Rachel says:

    How can glutathione be naturally be naturally increased in the body?

  • Sung Min says:

    So, if this mutation is in the genes, is it hereditary?

  • Donna says:

    what is the best way to find out if you have this mutation?

  • DW says:

    Dear Dr. Lam,
    This is all new to me, as I was just diagnosed this summer with more medical issues, including intercistial cystitis. For some reason the urologist tested me and I have the MTHRFR 1298C mutation I think, and a lot of medical issues. I also have a son with autism , and most of what you mentioned above on the list I either have, or our family does. That said I brought up this gene concern to my PCP today and she had no idea what I was talking about, and said they don’t do genetics there, and to talk to my immunologist. Huh? Are Drs. Not suppose to help their patients figure out what is making them sick? In addition to several of above list my folate and B12 just came back as high, but she didn’t seem worried as they were not low , which is what they were checking for . I also have DYSAUTONOMIA and chronic thrush…can those be caused by this gene issue?

  • Nancy says:

    I wantedd to add I have taken one cap of the Beta Plus(oxbile supplement). It brought on the pressure under my right ribs. I have been to a functional med doc regarding this issue and I still don’t know if this pressure is the liver or the gallbladder.
    I had planned to start a colon cleanse…then lead up to the liver cleanse…to speed up healing.
    What are your thoughts?
    Thank you very much.

    • Dr.Lam says:

      Talk to your doctor. A colon cleanse can make you worse if you are not careful, especially if you have other issues going on.


  • Nancy says:

    Great article, Doctor.
    I have both 677 and 1298 single copy variant.
    I have been using Pure Encapsulations Ultra B with PQQ, one cap per day.
    Been on two months and they have been so helpful for my energy and my skin and I’m sure on the cellular level. Lucky me.
    I’m strictly keto.
    I have leaky gut, yeast-intestinal, Mercury and cadmium detected, ca on carotid artery skull base.
    Pancreatic insufficiency, and pressure after eating fats which at present I’m trying Beta Plus by Biotics.
    I am interested in taking glutathione.
    What would you recommend?
    Thank you.
    I am interested in taking glutathione.

  • Kim says:

    I am compound heterozygous for both MTHFR C677t and A1298C, in December I started taking 5mg of methyl folate along with 5 mg of methyl B-12 (Methylcobalamin). I had my levels checked this week and the folate is normal but my B-12 is over 1500. I’ve been taking the other suggested supplements for MTHFR such as P5P, fish oil, vitamin d, and small amounts of glutathione. I have hypothyroidism and am currently taking nature throid, which my levels are normal for now. My bloodwork recently showed I have high platelets, high ESR, and CRP. I’m not sure how to go about treating mthfr as what I’ve been doing isn’t working. Should I stop the B-12? What suggestions can you give me?

    Thank you so much for your help!

    • Dr.Lam says:

      It may not be working because your focus is on the numbers. Your body may be telling you it’s not the way to go.


  • B says:

    I have AFS, thyroid issues and Lyme Disease. I think the Lyme is causing all the others. I want to take glutathione to support my herx reactions to my Lyme treatment. Do you see that being a problem? I suspect MTHFR as I had some abnormal Iron results. Mostly low Iron except high Saturation %.

    • Dr.Lam says:

      It can be a problem and it can make your herx worse. Don’t focus too much on the labs. You can be mislead. A lot also depends on your clinical state. What is right in theory tends to not be right in cases like yours with all these issues going on. Click Laboratory Testing for more information.


  • Caleb says:

    What is adjunct therapy? and can it benefit other nutritional issues?

  • Jeannie says:

    I have the mthfr c677T homo mutation however my b12 is the high end of normal (837). I cannot tolerate the methyl folate nor can I tolerate the NAC as I have tried both and they both make me very achy and unwell feeling. Would I be ok just taking the glutathione? I currently have hashimotos since July 2016 and have extreme fatigue, achiness. TPO 90.

    Thank you!

    • Dr.Lam says:

      Not everyone with MTHFR can tolerate the supplements you mentioned. Glutathione is a possibility but it has its risk. 10-15% of normal have high TPO but no Hashi. Be careful.


  • Jacqueline says:

    Thank you a thousand times Dr Lam. After seeing many doctors and getting worse for over 16 years. I discovered your website education and books, my health is now being restored. I pray good health and long life to you.

  • Jonathan says:

    Is MTHFR a preventable condition?

    • Dr.Lam says:

      It is a genetically linked condition. Not everyone who is afflicted need to be treated. Sometimes treatment can make things worse for some people.

      Dr Lam

  • Glenn says:

    You mention that not all sufferers need to be treated, but is this this the case for AFS sufferers as well? Or if you have both, should you treat the MTHFR first?

  • L says:

    Hello Dr. Lam,

    Is liposomal glutathione safe to use for those with MTHFR mutations in pregnancy?


  • Marie says:

    Great article! I just recently found I I am compound MTHFR: heterozygous C677T and homozygous A1298C. A rare mutation from what I understand. Homocysteine is 16! It explains a lot of my symptoms….chronic insomnia, low libido, low mood, brain fog, autoimmune disease, hormone disregulation….I feel blessed that I am able to work and function, although not optimally. I just received my methyl b-vitamins and my TMG. I will start slowly and hope they help.

  • Rolph says:

    Interesting but kind of scary to think of this. Do these signs show up at a certain age?

  • Desperate Mom says:

    Can you advise on what would be a good protocol to ask for at ER? -The girl is 22 years old. Main symtpoms: shortness of breath –can sometimes be acute, many panic attacks, constant anxiety, is in advanced stages of adrenal fatigue, bed-ridden, hear pains, odd pains in random places, does not tolerate many medicines or supplements, has MTHFR too. ER usually gives her Ativan (which her doctor already has her taking, because he does not understand adrenal fatigue..) and then they send her home because they say all her vitals are “fine” and they can’t find anything wrong. Instead they say she needs psychiatrist. (Psychiatrist didn’t help either!) She goes home very exhausted from the ordeal and feeling no better. What would be a suggested treatment to ask for in ER? –We also have an appointment with a Integrative doctor who treats AF, but until then she still has frequent ER visits when she feels like death is imminent.. Please advise!
    Thank you!! –Desperate Mom

    • Dr.Lam says:

      The story you presented is very typical of someone who is in advanced stages of AFS but conventional medicine does not recognize. Until you find a doc who truly understands after all work up are normal, you will likely be passed from one speciality to another. You can start by reading my book. We do have a telephone coaching program for those who qualify.

      Dr Lam

      • Desperate Mom says:

        I did sign up for your newsletter and downloaded your book too. I just finished reading it. Thank you!

  • Kim says:

    My son and I have two copies of the 1298 homozygous genes. I’m not sure wether I should give him the HPV vaccine or not, can this be dangerous to my son? I would like him to be protected against this virus though. His doctor doesn’t know a lot about MTHFR but he knows that around 14,000 teens get diagnosed with it per year. Can this vaccine be dangerous to my son or will it help him?

    • Dr.Lam says:

      Only his doctor who correlates the clinical condition can make that decision because each person is different.

      Dr Lam

    • F. Lehmann says:

      Please do NOT give your son the HPV vaccine. It is NOT needed and is VERY dangerous. Please read the vaccine ingredients list at the CDC website. Also read all the adverse reactions that have been associated with this vaccine. Most patients who contract HPV clear it in 6 months to a year. If you have MTHFR you do not clear the toxins, heavy metals, or viruses in the vaccines well at all. This can and will complicate your son’s medical condition. Believe me, I would not tell you this if I were not a nurse who used to believe in vaccines. I have seen with my own two eyes the damage the vaccines do to our children and the HPV vaccine is the WORST. And who says take the vaccine? The CDC, who profits from the sale of billions of dollars of vaccines. Yes, they purchase and sell vaccines, which is a huge conflict of interest. The best way to combat HPV, cancer, and other diseases is with good nutrition, Vitamin C, and other recommended treatments for good methylation. Methylation is the detox pathway of the body and if its not working well, the body cannot function well. Correct those deficiencies and the body has an amazing ability to heal itself!

  • Spencer says:

    There seems to be more and more info about gene related issues. Is there a “most-likely” list I should be screened for?

    • Dr.Lam says:

      There is no harm to screen, but do not rely too much on the lab but more on your clinical condition. Given the myriad of tests available nowadays, it is easy to find things that are “abnormal”, but bear in mind that not every “abnormality” needs to be fixed, and often times, the fix can bring negative results.

      Dr Lam

  • Heather says:

    I feel like I have a sensitivity to glutathione. Am i being a hypochondriac or have you heard of people w/ that sensitivity. And if that is the case what other supplements could i use for a similar effect?

    • Dr.Lam says:

      Sensitivity to glutathione is not uncommon. it is a sign that something deeper may be problematic, such as sulfur issues and liver congestions. The key is to focus on the underlying cause and help the body with that as first step rather than simply switching to others because glutathione is such as wonderful compound.

      DR Lam.

  • Jenifer says:

    Hi Dr.Lam
    Hope all is well ?
    As I have to you my saliva test showed a flat line of adrenal fatigue, low cortisol, and progesterone. My nutritionist gave be b12 (methylcobalim) 3000mcg 50000% and folate methyltetrahydrofolate 400mcg 100% and I feel I am more fatigued, can’t even grocery shop. If memory serves I feel I’ve gotten more tired after the supplement unless its coincidence.

    And yes couldn’t agree more with the glutathione. I’ve been reading about all this for 6 years.
    What is your take on the vitamins?
    Thank u! jennifer

    • Dr.Lam says:

      methylB12 is designed to stimulate the body, and the methyfolate will do similar. They are to act as catalyst to support MTHFR. The problem sometimes, these supplements can make the body worse in a setting of AFS because the body is not ready. Not every MTHFR needs to be treated. If you have AFS, you need to focus on that.

      Dr Lam.

  • Mary says:

    Our family doesn’t have a history of any major medical problems besides assorted cancers, but there is an abundance of those with depression, anxiety and bipolar disorder. My dad was born with a cleft palette and scoliosis, as well as growing up to be diagnosed with bipolar disorder and seasonal depressive disorder, and most of our living family suffers from migraines that seem to be tension related. Should we consider being screened?

    • Dr.Lam says:

      There is no harm ,but because it is quite common, you need to be careful not to be over relying on lab. It can be confusing,and not every abnormality needs to be dealt with as sometimes it can get worse with aggressive methylation approaches when the adrenals are weak. A detailed history by a knowledgeable professional is your best bet .

      Dr Lam

  • Neil says:

    Hi Dr Lam

    Would you know why in the past I got severe anxiety as responses to stressful events after I took sam-e supplement?


  • Jennifer says:

    Hi Dr.Lam
    Hope all is well…
    I know I have at least one MTHFR issue. I will have a test soon. My adrenals are flatlined, low cortisol, and progesterone. (My cortisols used to be high) I’ve gotten worse over the last year.
    Chemically sensitive, hypoglycemia on a stricter paleo diet my blood sugars are lower ? adrenal fatigue, anxiety, intolerant to heat, gluten intolerant, now staying away form sulfur and histamine foods. My nutritionist put me on apex energetics k-15 adrenal cream, niacinamide, and riboflavin. I feel like the nicinamide lowrers my blood sugar ? I am very familiar with glutathione. Also leaky gut, candida ugh sound like a train wreck. I also have Chiari 1 malformation.
    I did talk to your wife, very sweet. Just wanted your opinion about the supplements and overall. Thank you so much. Health & Joy Jennifer

  • Sheila says:

    I’m so thankful for this article as well as all the comments and Dr. Lam’s replies! Will need to check out now to get glutathione myself. Thanks again

  • gabrielle garrison says:

    Dr. Lam what is the best brand of Glutathione to take if one has MTHFR heterzygous mutation

    • Dr.Lam says:

      you want to focus on methyl folate and mythalated B12. If you want focus on glutathione, I suggest my Liponano Glutathione available at

      Dr Lam

  • jill d says:

    Dr. Lam – How can you reduce high B12 levels in the blood?
    I have had elevated B12 levels for 2 years (1200 pmol/L.)
    I stopped taking vitamins with B12 in them about a year ago and am only now learning about MTHFR.
    Have you read this? –

    • Dr.Lam says:

      you need to get rid of the underlying cause of the elevation as high vit B12, if you are not on supplemnets, is a symptom and not a disease on its own.

      Dr Lam

  • Jen says:

    Dr. Lam,
    I was diagnosed with B12 deficicency in May 2016. I immediately began injections of 1000 mcg cyanocobalamin as well as 5000 mcg oral methylcobalamin because I was experiencing severe neurological symptoms. Initially a couple of my symptoms resolved but with my last two injections, I have been getting progressively worse. My last injection was on Monday and I have never felt worse. I am concerned that I unknowingly had the MHTFR mutation while I was taking the cyanocobalamin injections. Could my regression of symptoms be due to toxicity? I am scared that I may have multiple heavy metal toxicities along with a lot of other deficiencies because of the possible MHTFR mutation. I will be getting tested for the mutation but I cannot wait to handle this mess I’ve caused. Not to mention the possible adrenal fatigue. I fear that I may not even make it through the weekend as terrible as I feel…
    Please help me!!!
    Thank you!

    • Dr.Lam says:

      Your body may be sending you signal that it does not like your appraoch. OVer methylation can have many problems, and even if you have MTHFR, you have to be very careful with methylation if your intrinsic system is fragile and weak internally. The extra b12 simply sets of the cascade of decompensation.

      Dr Lam

  • Jocelyn Harris says:

    Dr. Lam,

    I have heterozygous A1298C and C677T and AFS – diagnosed Fibromyalgia 10
    Years ago. Currently using B12 and methylfolate therapy. Considering glutathione IV and alpha lipoic acid IV therapy. What are your thoughts on this – would you recommend both? Which one first? Thank you!

    • Dr.Lam says:

      Glutathione is an expansive short term fix at best is you dont address the root issues. At the right time and place, it dose have some effect. We seldom use IV because it is not a long term solution

      Dr Lam

  • Phoenix says:

    Hi Dr. Lam, what percentage of the US population is affected by this?

    • Dr.Lam says:

      Roughly 40% of Americans are carriers of MTHFR deficiency, while 10% have the condition, according to some report. It is very important to note that not every deficiency needs to be fixed when AFS is present as often the treatment can make AFS worse.

      Dr Lam.

  • Ana says:

    Is glutathione a substance a body would naturally create? If not what is it precisely and what other benefits does it have in the body?

      • Julie newcomb says:

        Dr. Lam, I am curious and extremely disappointed in your solution for helping the body with glutathione. It’s been proven in many studies (most notorious with Dr Gerson therapy), that coffee enemas improve glutathione production. Why not go straight to the source and in the meantime rid the body of toxins. This also relieves pain and ibs symptoms. Sincerely Julie

        • Dr.Lam says:

          Your point is well noted. As compare to normal people, most advance AFS sufferers cannot tolerate detoxification well and in fact often crashes. This has been our clinical experience. They are quite weak internally . Many have tried coffee enema and got worse. We need to do the right thing at the right time, when they are stronger.

          Dr Lam

  • Alfonso says:

    Can environmental exposure to anything cause MTHFR?

  • Cherish says:

    I have adrenal fatigue and MTHFR which one would I want to work on first?

    • Dr.Lam says:

      Most people do better with AFS first especially if you are in advance stages. Treating MTHFR often entails stimulatory compounds that can make AFS worse or mask the underlying root issues.

      Dr Lam

  • Brad says:

    How common is this occurrence?

  • Sebastian says:

    srry, my liver enzymes are normal! 😉

  • Sebastian says:

    I have elevated Cobalamin (B12) Levels and Folic Acid Levels in my Blood. Liver Enzymes are not normal. I am very tired on some days and I feel dizzy without any reason. In my country (Austria), Drs dont know about MTHFR. Should I boost my methylation with Sam-e or with TMG? I can’t afford a genetic testing. Best regards

    • Dr.Lam says:

      increase methylation may or may not help. you should focus on your body and what it is telling you in terms of symptoms to start and find a nutritionally oriended doctor who can put all the pieces together so you have a comprehensive plan going forward rather than patching symptoms. Even if methylation helps you, you may not be doing the right thing long term so be careful.

      Dr Lam.

  • Victoria says:

    I’m really glad I found this article, what an interesting read!

  • Roy says:

    Hi Dr. Lam. Do you think MTHFR mutations will become part of the standard screening for immune system issues?

  • Jeanine isenhoff says:

    Dr Lam , my 13 year old had high B12 of 1200 then rechecked at 1300 , in addition a high (relative)of lymphocytes and a low % neutrophils. I got a referral from her primary to hematology but the dr was not concerned , hematology said he referred me because “mom was nervous”When I asked if it should be rechecked the hematologist said no need to recheck if she is “feeling well “.
    My daughter has daily headaches and has had social anxiety in the form of selective mutism since kindergarten . I wouldn’t exactly call that feeling well . Luckily I came across some info on this MTHFR issue and am going to have a test for that in addition to some food allergy and nutritional status testing . It amazes me that a pediatric hematologist has no knowledge of any of this and would tell me to just stop worrying about it everything is fine. She said “we don’t check b12 in kids”
    I had asked to have it checked because my daughter is vegetarian and occasionally eats eggs but that is it on animal products .
    Why exactly is the b12 high with the MTHFR deficit?

    • Dr.Lam says:

      That is not uncommon. With methylation problem, the unmethylated forms gets accumulated since it is not fully converted to the metylated form. This accumulation, measured by serum , will show high total b12.

      Dr Lam.

  • Jacob says:

    What percentage of people in the US suffer from this problem?