Progesterone is best absorbed where the skin is relatively thin and well supplied with capillary blood flow. Areas such as face, neck, upper chest, and inner arms are good areas. Spread out to as big an area as possible for maximum absorption and allow as much time for absorption as possible .
Therefore apply at bedtime is best if you are applying it once a day. Twice a day application is best.
Rotate to different areas to avoid saturation in any one particular site.
Here is a sample rotational application protocol:
Day 1 morning: Apply to the right side of the back of the neck.
Day 1 before bed: Apply to the left side of the back of the neck.
Day 2 morning: Apply to the right wrist area, with palm facing up.
Day 2 before bed: Apply to the left wrist area , with palm facing up.
Day 3 morning: Apply to the underside of the right upper arm.
Day 3 before bed: Apply to the underside of the left upper arm.
Repeat this cycle from day 4 onwards. In other words, day 4 will be the same as day 1, and day 5 will be the same as day 2, etc.