Pantethine – An Extremely Useful Nutrient

By: Michael Lam, MD, MPH

Pantethine can be found in supplements There are few natural compounds more powerful than pantethine and its relative pantothenic acid. For decades pantothenic acid is one of the essential nutrients used to help adrenal function. In fact, it is a good substitute for prednisone, a drug which has horrible side effects, but is very valuable in the treatment of auto immune diseases including arthritis, allergies, and colitis.

Because it mimics prednisone and can help treat inflammatory issues, pantethine can also help to bring balance back to the NEM Stress Response, which if there is an issue of detoxification and inflammation and hormone balances, usually means that the NEM Stress Response is included. The NEM Stress Response is made of six systems in our body, which create a coordinated response when triggered by a stressful stimulus. This response is often supported through correct levels of hormones, nutrients, and neurotransmitters. If there is an imbalance, issues occur and issues such as adrenal fatigue, and excessive inflammatory responses and metabolic issues occur. It is important to keep the body supported to maintain health and balance.

The Role of Pantethine Within the Body

Once inside the body, pantothenic acid forms a substance called pantethine, which is further converted into an enzyme called “Co-enzyme A.”

Co-enzyme A is an extremely important compound and is essential in the metabolism of protein, fat, and carbohydrates. It is also the starting point for the body’s production of adrenal steroids, cholesterol, bile, and haemoglobin.

While pantothenic acid ultimately leads to the creation of co-enzyme A, the use of pantethine is a much faster way to achieve the same effect as pantothenic acid and with increased potency. Pantethine is critical to the management of auto-immune disorders as well as adrenal fatigue. Pantethine allows the adrenal glands to generate more cortisone which is an anti-stress hormone. With more cortisone produced, the body’s inflammatory response is reduced.

For maximum effect, it should be used in conjunction with a high dose nutritional cocktail of vitamin C, lysine, proline, bioflavonoids, pine bark extract, glycine, carnitine, magnesium, frutooligosaccharides, glutamine, and ascorbyl palmitate.

Pantethine is an excellent choice when it comes to reduction of triglyceride in the body. A daily dose of 900 mg has been shown to reduce triglyceride by up to 32% as well as a 19% drop in total cholesterol and a 21% drop in LDL ( the “bad” cholesterol) cholesterol . At the same time, HDL (the “good” cholesterol) rose by 23%. Pantethine also protects the heart and arteries and acts synergistically with vitamin E against cholesterol build up.

Pantethine’s role in optimum heart health cannot be under-estimated. By generating more Co-enzyme A, the heart muscle’s metabolic rate is enhanced, thereby increasing the heart contractile forces. With a stronger contraction, a longer relaxation phase is possible, resulting in the slowing of heart rate. In addition, pantethine also helps to increase the production of omega-3 fatty acid in the body ( EPA, DHA, and other essential oils). Omega-3 fatty acids also have powerful anti-inflammatory effects and reduces the clot promoting fats in cell membranes. Most spectacularly, there are no side effects.

Pantethine is also an excellent nutrient when it comes to 2 major gastrointestinal problems, namely colitis and Crohn’s disease. A daily dose of 900-1200 mg matched with 900-1200 mg of pantothenic acid will drastically improve those with Crohn’s disease and colitis. The normal waiting time for effects to kick in is 4 to 8 weeks, but many have reported benefits in much shorter time. Pantethine also helps beneficial bacteria to grow in the intestines. It helps the body get over yeast overgrowth and accumulation of other toxic substances such as formaldehyde.

Pantethine is therefore a natural detoxifier.

Pantothenic acid, while not as strong as pantethine, does have it’s own role. In high doses (up to 10 grams ) a day, it can help with acne. Calcium pantothenate is an excellent nutrient for gout when taken at 800-1200 mg in 4 divided doses per day. Some people have reported reduction in inflammation and improvement of symptoms in burning foot syndrome. It is also used in conjunction with non-steroidal anti-inflammatory drugs for arthritis.

Pantethine Summary

In summary, pantethine is a remarkably safe and extremely valuable natural dietary supplement. It is used in a variety of settings, with the most important being lipid balancing and in combating adrenal fatigue. The usual dosage of pantethine is 900-1500 mg a day in divided dosages.

Dr. Lam’s Key Question

Pantothenic acid is the precursor to pantethine. Both have unique characteristics.

Pantethine can be found in supplements
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Dr Lam, I wanted to let you know how much I am enjoying your cookbook! It's not just the healthy recipes, but the great information you provide as well. Thank you so much for writing your cookbook and sharing the information you have learned with us. I have adrenal fatigue and it is very hard to deal with and it is not easy to find good information.


  • Wes says:

    In this article you mention pantethine having a similar effect as prednisone. With that being said, my question is if pantethine would be helpful or harmful to be taken in the morning when my blood results show elevated morning cortisol levels. I’m not sure if pantethine is going to have adaptogenic like properties and stabilize cortisol or drive it higher.. Also, 1 month ago I had saliva cortisol testing done showing depressed morning cortisol, immediate blood tests reveal morning cortisol levels are actually elevated. Is this fluctuation normal in AFS? I have thyroid disease, leaky gut and suspected AFS by the way.

    • Dr.Lam says:

      Pantethine is a necessary cofactor to make steroid, but it is not a steroid. Your situation is quite complex and professional help should be sought. I am afraid too simplistic thinking may mislead you

      Dr Lam

  • Charmaine says:

    I recently had a total abdominal hysterectomy with ovaries remaining.
    I am insulin resistance. 30uu/ml
    Sugar is 8mmol/L. I also had H Pylori for which I took 2 rounds of antibiotics.

    I have low iron. Low cortisol and low vitamin D. I probaby have other vitamin deficiencies.

    I also experience heart burn which sometimes does get severe if I eat certain food or wait too long between meals.

    I also suffer with bouts of dizziness on a daily basis and I get tired very easily. When I get dizzy I feel like my eyes cannot focus. I also have foggy brain.

    I am taking a mix of medical and homeopathic medication.

    Do you think I have a list of unrelated issues or is there one diagnosis for what I have.
    Can I reverse all of this?

    • Dr.Lam says:

      Many things appear to be at play here. There may be interconnections but what those are cannot be known without a more detailed history that can take upwards of 30 minutes to sort out.

      DR Lam